Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp210 | Diabetes: Pharmacotherapy | ECE2019

Empagliflozin inhibits apoptosis of pancreatic beta-cells through amelioration of ER-stress.

Nasiri-Ansari Narjes , Dimitriadis Georgios K. , Angelousi Anna , Tsara Anna , Lembesis Panayiotis , Kiaris Hippokrates , Papavassiliou Athanasios G. , Randeva Harpal S. , Kassi Eva

Introduction: Type 2 diabetes mellitus (T2DM) is characterized by progressive impairment/ loss of pancreatic beta cell function Activation of endoplasmic reticulum (ER) stress by glucose variation has been suggested as an essential step towards beta cell dysfunction. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are widely used in the treatment of T2DM considering their beneficial cardiometabolic sequalae. In the present study, we aimed to investigate the effect of Empag...